Polymorphic variability in the IL-1β promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1β production

Interleukin (IL)-1β is a cytokine released as part of innate immune response to Plasmodium falciparum. Since the role of IL-1β polymorphic variability in conditioning the immunopathogenesis of severe malarial anemia (SMA) remains undefined, relationships between IL-1β promoter variants (-31C/T and -...

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Main Authors: Ouma, Collins, Davenport, Gregory C., Awandare, Gordon A., Keller, Christopher C., Were, Tom, Otieno, Michael F., Vulule, John M., Martinson, Jeremy, Ong'echa, John M., Ferrell, Robert E., Perkins, Douglas J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723855/
https://ncbi.nlm.nih.gov/pubmed/18781863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/592055
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