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Retinoic acid increases Foxp3(+) regulatory T cells and inhibits development of Th17 cells by enhancing TGF-β-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression

The de novo generation of Foxp3(+) regulatory T (Treg) cells in the peripheral immune compartment and the differentiation of Th17 cells both require TGF-β, and IL-6 and IL-21 are switch factors that drive the development of Th17 cells at the expense of Treg generation. The major vitamin A metabolite...

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Detalhes bibliográficos
Main Authors: Xiao, Sheng, Jin, Hulin, Korn, Thomas, Liu, Sue M., Oukka, Mohamed, Lim, Bing, Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722959/
https://ncbi.nlm.nih.gov/pubmed/18684916
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