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Effects of overexpression of Huntingtin proteins on mitochondrial integrity
Huntington’s disease (HD) is caused by an expansion of a CAG trinucleotide sequence that encodes a polyglutamine tract in the huntingtin (Htt) protein. Expansion of the polyglutamine tract above 35 repeats causes disease, with the age of onset inversely related to the degree of expansion above this...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2722218/ https://ncbi.nlm.nih.gov/pubmed/19039036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn404 |
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