Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

Cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is a critical negative regulator of immune responses. Uniquely among known inhibitory receptors, its genetic ablation results in a fulminating and fatal lymphoproliferative disorder. This central regulatory role led to the development of antibodie...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Peggs, Karl S., Quezada, Sergio A., Chambers, Cynthia A., Korman, Alan J., Allison, James P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2009
Ämnen:
Brief Definitive Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722174/
https://ncbi.nlm.nih.gov/pubmed/19581407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20082492
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