Long term impact of CTLA4 blockade immunotherapy on regulatory and effector immune responses in patients with melanoma

BACKGROUND: We previously reported early on-treatment significant modulation in circulating regulatory T cell (Treg), myeloid derived suppressor cells (MDSC) and antigen-specific type I CD4+ and CD8+ T cells that correlated with clinical outcome in regionally advanced melanoma patients treated with...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Retseck, Janet, Nasr, Alexis, Lin, Yan, Lin, Huang, Mendiratta, Prateek, Butterfield, Lisa H., Tarhini, Ahmad A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6033230/
https://ncbi.nlm.nih.gov/pubmed/29973204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1563-y
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