Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a diverse spectrum of cancers, and its pharmacological blockade has emerged as an anti-tumor strategy. While nearly all known Hh pathway antagonists target the transmembrane protein Smoothened (Smo), small molecul...

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Main Authors: Hyman, Joel M., Firestone, Ari J., Heine, Vivi M., Zhao, Yun, Ocasio, Cory A., Han, Kyuho, Sun, Mark, Rack, Paul G., Sinha, Surajit, Wu, Jason J., Solow-Cordero, David E., Jiang, Jin, Rowitch, David H., Chen, James K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2009
主題:
Physical Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2721821/
https://ncbi.nlm.nih.gov/pubmed/19666565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907134106
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