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The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression
The SOCS (Suppressors of Cytokine Signalling) family of proteins inhibit the cytokine induced signalling cascade, in part by promoting the ubiquitination of signalling intermediates that are then targeted for proteasomal degradation. This activity relies upon an interaction between the SOCS box doma...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2009
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720833/ https://ncbi.nlm.nih.gov/pubmed/19385048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.01.024 |
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