Smurf2 Induces Degradation of GSK-3β and Upregulates β-Catenin in Chondrocytes: A Potential Mechanism for Smurf2-Induced Degeneration of Articular Cartilage

We have previously demonstrated that Smurf2 is highly expressed in human osteoarthritis (OA) tissue, and overexpression of Smurf2 under the control of the type II collagen promoter (Col2a1) induces an OA-like phenotype in aged Col2a1-Smurf2 transgenic mice, suggesting that Smurf2 is located upstream...

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Autors principals: Wu, Qiuqian, Huang, Jason H, Sampson, Erik R, Kim, Kyung-OK, Zuscik, Michael J, O’Keefe, Regis J., Chen, Di, Rosier, Randy N.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720571/
https://ncbi.nlm.nih.gov/pubmed/19481076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2009.05.019
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