Regulation of Embryonic Endochondral Ossification by Smurf2

Smurf2 is an E3 ubiquitin ligase that targets TGF-β receptor activated Smad2 and Smad3 for the proteasome in primary articular chondrocytes, thus stimulating their hypertrophic differentiation. Comparatively, how Smurf2 functions in growth plate chondrocytes in a developing long bone is an open ques...

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Bibliografiske detaljer
Main Authors: Wu, Qiuqian, Wang, Meina, Zuscik, Michael J., Chen, Di, O’Keefe, Regis J., Rosier, Randy N.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636972/
https://ncbi.nlm.nih.gov/pubmed/18176945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.20563
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