Induction of an Osteoarthritis-like Phenotype and Degradation of Phosphorylated Smad3 bySmurf2 in Transgenic Mice

OBJECTIVE: To determine whether Smurf2, an E3 ubiquitin ligase known to inhibit transforming growth factor β (TGFβ) signaling, is expressed in human osteoarthritic (OA) cartilage and can initiate OA in mice. METHODS: Human OA cartilage was obtained from patients undergoing knee arthroplasty. Samples...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Wu, Qiuqian, Kim, Kyung-Ok, Sampson, Erik R., Chen, Di, Awad, Hani, O'Brien, Todd, Puzas, J. Edward, Drissi, Hicham, Schwarz, Edward M., O'Keefe, Regis J., Zuscik, Michael J., Rosier, Randy N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636703/
https://ncbi.nlm.nih.gov/pubmed/18821706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23946
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados