Induction of an Osteoarthritis-like Phenotype and Degradation of Phosphorylated Smad3 bySmurf2 in Transgenic Mice

OBJECTIVE: To determine whether Smurf2, an E3 ubiquitin ligase known to inhibit transforming growth factor β (TGFβ) signaling, is expressed in human osteoarthritic (OA) cartilage and can initiate OA in mice. METHODS: Human OA cartilage was obtained from patients undergoing knee arthroplasty. Samples...

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Bibliografiset tiedot
Päätekijät: Wu, Qiuqian, Kim, Kyung-Ok, Sampson, Erik R., Chen, Di, Awad, Hani, O'Brien, Todd, Puzas, J. Edward, Drissi, Hicham, Schwarz, Edward M., O'Keefe, Regis J., Zuscik, Michael J., Rosier, Randy N.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636703/
https://ncbi.nlm.nih.gov/pubmed/18821706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.23946
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