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Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein

Telomerase is an essential cellular ribonucleoprotein (RNP) that solves the end replication problem and maintains chromosome stability by adding telomeric DNA to the termini of linear chromosomes1–3. Genetic mutations that abrogate normal assembly of telomerase RNP cause human disease4. It is thus o...

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Bibliografske podrobnosti
Main Authors: Stone, Michael D., Mihalusova, Mariana, O’Connor, Catherine M., Prathapam, Ramadevi, Collins, Kathleen, Zhuang, Xiaowei
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720403/
https://ncbi.nlm.nih.gov/pubmed/17322903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05600
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