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Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein

Telomerase is an essential cellular ribonucleoprotein (RNP) that solves the end replication problem and maintains chromosome stability by adding telomeric DNA to the termini of linear chromosomes1–3. Genetic mutations that abrogate normal assembly of telomerase RNP cause human disease4. It is thus o...

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Hlavní autoři: Stone, Michael D., Mihalusova, Mariana, O’Connor, Catherine M., Prathapam, Ramadevi, Collins, Kathleen, Zhuang, Xiaowei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720403/
https://ncbi.nlm.nih.gov/pubmed/17322903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05600
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