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Stepwise protein-mediated RNA folding directs assembly of telomerase ribonucleoprotein

Telomerase is an essential cellular ribonucleoprotein (RNP) that solves the end replication problem and maintains chromosome stability by adding telomeric DNA to the termini of linear chromosomes1–3. Genetic mutations that abrogate normal assembly of telomerase RNP cause human disease4. It is thus o...

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Bibliografische gegevens
Hoofdauteurs: Stone, Michael D., Mihalusova, Mariana, O’Connor, Catherine M., Prathapam, Ramadevi, Collins, Kathleen, Zhuang, Xiaowei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720403/
https://ncbi.nlm.nih.gov/pubmed/17322903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature05600
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