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Mutational and functional analysis of Large in a novel CHO glycosylation mutant
Inactivating mutations of Large reduce the functional glycosylation of α-dystroglycan (α-DG) and lead to muscular dystrophy in mouse and humans. The N-terminal domain of Large is most similar to UDP-glucose glucosyltransferases (UGGT), and the C-terminal domain is related to the human i blood group...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720279/ https://ncbi.nlm.nih.gov/pubmed/19470663 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwp074 |
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