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Mutational and functional analysis of Large in a novel CHO glycosylation mutant

Inactivating mutations of Large reduce the functional glycosylation of α-dystroglycan (α-DG) and lead to muscular dystrophy in mouse and humans. The N-terminal domain of Large is most similar to UDP-glucose glucosyltransferases (UGGT), and the C-terminal domain is related to the human i blood group...

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Bibliografiske detaljer
Main Authors: Aguilan, Jennifer T, Sundaram, Subha, Nieves, Edward, Stanley, Pamela
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720279/
https://ncbi.nlm.nih.gov/pubmed/19470663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwp074
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