Activated 4E-BP1 represses tumourigenesis and IGF-I-mediated activation of the eIF4F complex in mesothelioma

BACKGROUND: Insulin-like growth factor (IGF)-I signalling stimulates proliferation, survival, and invasion in malignant mesothelioma and other tumour types. Studies have found that tumourigenesis is linked to dysregulation of cap-dependent protein translation. METHODS: The effect of IGF stimulation...

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Main Authors: Jacobson, B A, De, A, Kratzke, M G, Patel, M R, Jay-Dixon, J, Whitson, B A, Sadiq, A A, Bitterman, P B, Polunovsky, V A, Kratzke, R A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720234/
https://ncbi.nlm.nih.gov/pubmed/19603014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605184
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