Targeting Eukaryotic Translation in Mesothelioma Cells with an eIF4E-Specific Antisense Oligonucleotide

BACKGROUND: Aberrant cap-dependent translation is implicated in tumorigenesis in multiple tumor types including mesothelioma. In this study, disabling the eIF4F complex by targeting eIF4E with eIF4E-specific antisense oligonucleotide (4EASO) is assessed as a therapy for mesothelioma. METHODS: Mesoth...

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Main Authors: Jacobson, Blake A., Thumma, Saritha C., Jay-Dixon, Joseph, Patel, Manish R., Dubear Kroening, K., Kratzke, Marian G., Etchison, Ryan G., Konicek, Bruce W., Graff, Jeremy R., Kratzke, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832430/
https://ncbi.nlm.nih.gov/pubmed/24260583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0081669
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