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Dasatinib inhibits the growth of prostate cancer in bone and provides additional protection from osteolysis

BACKGROUND: Dasatinib is a small molecule kinase inhibitor that has recently been shown to inhibit Src family kinases (SFK) and also has activity against CaP. Of importance to metastatic CaP, which frequently metastasises to bone, SFK are also vital to the regulation of bone remodelling. We sought t...

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Autori principali: Koreckij, T, Nguyen, H, Brown, L G, Yu, E Y, Vessella, R L, Corey, E
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2720213/
https://ncbi.nlm.nih.gov/pubmed/19603032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605178
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