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Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110α
p110α (PIK3CA) is the most frequently mutated kinase in human cancer, and numerous drugs targeting this kinase are currently in pre-clinical development or early stage clinical trials. Clinical resistance to protein kinase inhibitors frequently results from point mutations that block drug binding; s...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720137/ https://ncbi.nlm.nih.gov/pubmed/18691552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.06.014 |
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