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Structures of Aβ-related peptide-monoclonal antibody complexes
Passive immunotherapy (PI) is being explored as a potential therapeutic against Alzheimer’s disease. The most promising antibodies (Abs) used in PI target the EFRH motif of the Aβ N-terminus. The monoclonal anti-Aβ Ab PFA1 recognizes the EFRH epitope of Aβ. PFA1 has a high affinity for Aβ fibrils an...
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| Autori principali: | , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2720063/ https://ncbi.nlm.nih.gov/pubmed/19385664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9001216 |
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