Molecular basis for passive immunotherapy of Alzheimer's disease

Amyloid aggregates of the amyloid-β (Aβ) peptide are implicated in the pathology of Alzheimer's disease. Anti-Aβ monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies. Consequently, passive immunization is being considered for treating Alzheimer&#...

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Detalhes bibliográficos
Main Authors: Gardberg, Anna S., Dice, Lezlee T., Ou, Susan, Rich, Rebecca L., Helmbrecht, Elizabeth, Ko, Jan, Wetzel, Ronald, Myszka, David G., Patterson, Paul H., Dealwis, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1994138/
https://ncbi.nlm.nih.gov/pubmed/17895381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705888104
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