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Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue-specific injury in experimental biliary atresia

Biliary atresia is a neonatal obstructive cholangiopathy that progresses to end-stage liver disease. Although the etiology is unknown, a neonatal adaptive immune signature has been mechanistically linked to obstruction of the extrahepatic bile ducts. Here, we investigated the role of the innate immu...

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Autori principali: Shivakumar, Pranavkumar, Sabla, Gregg E., Whitington, Peter, Chougnet, Claire A., Bezerra, Jorge A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719928/
https://ncbi.nlm.nih.gov/pubmed/19662681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38879
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