Loss of interleukin-12 modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia

BACKGROUND: Livers of infants with biliary atresia and of neonatal mice infected with rotavirus (RRV) have increased expression of interferon-gamma (IFNγ) and interleukin (IL)-12. While the expression of IFNγ regulates the obstruction of extrahepatic bile ducts by lymphocytes, the role of IL-12 in t...

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Autori principali: Mohanty, Sujit Kumar, Shivakumar, Pranavkumar, Sabla, Gregg, Bezerra, Jorge A
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2006
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479354/
https://ncbi.nlm.nih.gov/pubmed/16623951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-6-14
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