A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We...

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Autors principals: Church, Chris, Lee, Sheena, Bagg, Eleanor A. L., McTaggart, James S., Deacon, Robert, Gerken, Thomas, Lee, Angela, Moir, Lee, Mecinović, Jasmin, Quwailid, Mohamed M., Schofield, Christopher J., Ashcroft, Frances M., Cox, Roger D.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719869/
https://ncbi.nlm.nih.gov/pubmed/19680540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000599
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