Structure-Function Relationships in Miscoding by Sulfolobus solfataricus DNA Polymerase Dpo4: GUANINE N(2),N(2)-DIMETHYL SUBSTITUTION PRODUCES INACTIVE AND MISCODING POLYMERASE COMPLEXES

Previous work has shown that Y-family DNA polymerases tolerate large DNA adducts, but a substantial decrease in catalytic efficiency and fidelity occurs during bypass of N(2),N(2)-dimethyl (Me(2))-substituted guanine (N(2),N(2)-Me(2)G), in contrast to a single methyl substitution. Therefore, it is u...

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Main Authors: Zhang, Huidong, Eoff, Robert L., Kozekov, Ivan D., Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719408/
https://ncbi.nlm.nih.gov/pubmed/19542237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109014274
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