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Effect of N(2)-Guanyl Modifications on Early Steps in Catalysis of Polymerization by Sulfolobus solfataricus P2 DNA Polymerase Dpo4 T239W

Translesion DNA polymerases are more efficient at bypass of many DNA adducts than replicative polymerases. Previous work with the translesion polymerase Sulfolobus solfataricus Dpo4 showed a decrease in catalytic efficiency during bypass of bulky N(2)-alkyl deoxyguanosine (G) adducts with N(2)-isobu...

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Detalhes bibliográficos
Main Authors: Zhang, Huidong, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814591/
https://ncbi.nlm.nih.gov/pubmed/19969000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.071
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