Adapter-mediated Substrate Selection for Endoplasmic Reticulum-associated Degradation

During endoplasmic reticulum (ER)-associated degradation (ERAD), a relatively small number of ubiquitin ligases (E3) must be capable of ubiquitinating an assortment of substrates diverse in both structure and location (ER lumen, membrane, and/or cytosol). Therefore, mechanisms that operate independe...

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Bibliographic Details
Main Authors: Corcoran, Kathleen, Wang, Xiaoli, Lybarger, Lonnie
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719388/
https://ncbi.nlm.nih.gov/pubmed/19366690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808258200
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