Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes

Although it is conceivable that cancer preventive isothiocyanates (ITCs), a family of compounds in cruciferous vegetables, induce cell cycle arrest and apoptosis through a mechanism involving oxidative stress, our study shows that binding to cellular proteins correlates with their potencies of apopt...

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Autori principali: Mi, Lixin, Gan, Nanqin, Cheema, Amrita, Dakshanamurthy, Sivanesan, Wang, Xiantao, Yang, David C. H., Chung, Fung-Lung
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Protein Synthesis, Post-Translational Modification, and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719342/
https://ncbi.nlm.nih.gov/pubmed/19339240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901789200
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