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Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery

Unwanted or misfolded proteins are either refolded by chaperones or degraded by the ubiquitin-proteasome system (UPS). When UPS is impaired, misfolded proteins form aggregates, which are transported along microtubules by motor protein dynein towards the juxta-nuclear microtubule organizing center to...

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Main Authors: Mi, Lixin, Gan, Nanqin, Chung, Fung-Lung
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748326/
https://ncbi.nlm.nih.gov/pubmed/19682429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2009.08.047
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