p38 MAPK Is a Major Regulator of MafA Protein Stability under Oxidative Stress

Mammalian MafA/RIPE3b1 is an important glucose-responsive transcription factor that regulates function, maturation, and survival of β-cells. Increased expression of MafA results in improved glucose-stimulated insulin secretion and β-cell function. Because MafA is a highly phosphorylated protein, we...

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Hlavní autoři: Kondo, Takuma, Khattabi, Ilham El, Nishimura, Wataru, Laybutt, D. Ross, Geraldes, Pedro, Shah, Samit, King, George, Bonner-Weir, Susan, Weir, Gordon, Sharma, Arun
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2718751/
https://ncbi.nlm.nih.gov/pubmed/19407223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0482
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