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p38 MAPK Is a Major Regulator of MafA Protein Stability under Oxidative Stress
Mammalian MafA/RIPE3b1 is an important glucose-responsive transcription factor that regulates function, maturation, and survival of β-cells. Increased expression of MafA results in improved glucose-stimulated insulin secretion and β-cell function. Because MafA is a highly phosphorylated protein, we...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Endocrine Society
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2718751/ https://ncbi.nlm.nih.gov/pubmed/19407223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0482 |
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