Comparison of metal-dependent catalysis by HIV-1 and ASV integrase proteins using a new and rapid, moderate throughput assay for joining activity in solution

BACKGROUND: HIV-1 integrase (IN) is an attractive target for the development of drugs to treat AIDS, and inhibitors of this viral enzyme are already in the clinic. Nevertheless, there is a continuing need to devise new approaches to block the activity of this viral protein because of the emergence o...

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Main Authors: Andrake, Mark D, Ramcharan, Joseph, Merkel, George, Zhao, Xue Zhi, Burke, Terrence R, Skalka, Anna Marie
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
Assuntos:
Methodology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717984/
https://ncbi.nlm.nih.gov/pubmed/19563676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-6-14
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