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Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody*

BACKGROUND: To further our understanding of the structure and function of HIV-1 integrase (IN) we developed and characterized a library of monoclonal antibodies (mAbs) directed against this protein. One of these antibodies, mAb33, which is specific for the C-terminal domain, was found to inhibit HIV...

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Autors principals: Ramcharan, Joseph, Colleluori, Diana M, Merkel, George, Andrake, Mark D, Skalka, Anna Marie
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1539010/
https://ncbi.nlm.nih.gov/pubmed/16790058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-3-34
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