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Structural and Functional Analysis of Sulfolobus solfataricus Y-Family DNA Polymerase Dpo4-Catalyzed Bypass of the Malondialdehyde−Deoxyguanosine Adduct(,)

[Image: see text] Oxidative stress can induce the formation of reactive electrophiles, such as DNA peroxidation products, e.g., base propenals, and lipid peroxidation products, e.g., malondialdehyde. Base propenals and malondialdehyde react with DNA to form adducts, including 3-(2′-deoxy-β-d-erythro...

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Detalhes bibliográficos
Main Authors: Eoff, Robert L., Stafford, Jennifer B., Szekely, Jozsef, Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter, Marnett, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2009
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717710/
https://ncbi.nlm.nih.gov/pubmed/19492857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9003588
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