Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

Retrovirus assembly and maturation involve folding and transport of viral proteins to the virus assembly site followed by subsequent proteolytic cleavage of the Gag polyprotein within the nascent virion. We report that inhibiting proteasomes severely decreases the budding, maturation, and infectivit...

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Podrobná bibliografie

Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Schubert, Ulrich, Ott, David E., Chertova, Elena N., Welker, Reinhold, Tessmer, Uwe, Princiotta, Michael F., Bennink, Jack R., Kräusslich, Hans-Georg, Yewdell, Jonathan W.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2000
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087859/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.24.13057
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