Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

Retrovirus assembly and maturation involve folding and transport of viral proteins to the virus assembly site followed by subsequent proteolytic cleavage of the Gag polyprotein within the nascent virion. We report that inhibiting proteasomes severely decreases the budding, maturation, and infectivit...

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Detalhes bibliográficos
Main Authors: Schubert, Ulrich, Ott, David E., Chertova, Elena N., Welker, Reinhold, Tessmer, Uwe, Princiotta, Michael F., Bennink, Jack R., Kräusslich, Hans-Georg, Yewdell, Jonathan W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2000
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC27177/
https://ncbi.nlm.nih.gov/pubmed/11087859
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