Proteasome inhibition interferes with Gag polyprotein processing, release, and maturation of HIV-1 and HIV-2

Retrovirus assembly and maturation involve folding and transport of viral proteins to the virus assembly site followed by subsequent proteolytic cleavage of the Gag polyprotein within the nascent virion. We report that inhibiting proteasomes severely decreases the budding, maturation, and infectivit...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Schubert, Ulrich, Ott, David E., Chertova, Elena N., Welker, Reinhold, Tessmer, Uwe, Princiotta, Michael F., Bennink, Jack R., Kräusslich, Hans-Georg, Yewdell, Jonathan W.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2000
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC27177/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11087859/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.24.13057
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