Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

BACKGROUND: Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat to human health. Current DNT testing guidelines propose investigations in rodents, which require large numbers of animals. With regard to the “3 Rs” (reduction, replacement, and refinement) of animal testing...

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Main Authors: Moors, Michaela, Rockel, Thomas Dino, Abel, Josef, Cline, Jason E., Gassmann, Kathrin, Schreiber, Timm, Schuwald, Janette, Weinmann, Nicole, Fritsche, Ellen
Format: Artigo
Jezik:Inglês
Izdano: National Institute of Environmental Health Sciences 2009
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717141/
https://ncbi.nlm.nih.gov/pubmed/19654924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0800207
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