Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

BACKGROUND: Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat to human health. Current DNT testing guidelines propose investigations in rodents, which require large numbers of animals. With regard to the “3 Rs” (reduction, replacement, and refinement) of animal testing...

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Hlavní autoři: Moors, Michaela, Rockel, Thomas Dino, Abel, Josef, Cline, Jason E., Gassmann, Kathrin, Schreiber, Timm, Schuwald, Janette, Weinmann, Nicole, Fritsche, Ellen
Médium: Artigo
Jazyk:Inglês
Vydáno: National Institute of Environmental Health Sciences 2009
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717141/
https://ncbi.nlm.nih.gov/pubmed/19654924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0800207
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