Human Neurospheres as Three-Dimensional Cellular Systems for Developmental Neurotoxicity Testing

BACKGROUND: Developmental neurotoxicity (DNT) of environmental chemicals is a serious threat to human health. Current DNT testing guidelines propose investigations in rodents, which require large numbers of animals. With regard to the “3 Rs” (reduction, replacement, and refinement) of animal testing...

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Detalhes bibliográficos
Main Authors: Moors, Michaela, Rockel, Thomas Dino, Abel, Josef, Cline, Jason E., Gassmann, Kathrin, Schreiber, Timm, Schuwald, Janette, Weinmann, Nicole, Fritsche, Ellen
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2009
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717141/
https://ncbi.nlm.nih.gov/pubmed/19654924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.0800207
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