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Protein Reactivity of 3,4-Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite, is Dependent on both the Aldehyde and Catechol

Dopamine (DA) has been implicated as an endogenous neurotoxin to explain the selective neurodegeneration as observed for Parkinson's disease (PD). However, previous work demonstrated 3,4-dihydroxyphenylacetaldehyde (DOPAL) to be more toxic than DA. DOPAL is generated as a part of DA catabolism...

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Hlavní autoři: Rees, Jennifer N., Florang, Virginia R., Eckert, Laurie L., Doorn, Jonathan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717024/
https://ncbi.nlm.nih.gov/pubmed/19537779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx9000557
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