Frequent Missense and Insertion/Deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-Specific Variation in PrP

BACKGROUND: The cellular prion protein PrP(C) is encoded by the Prnp gene. This protein is expressed in the central nervous system (CNS) and serves as a precursor to the misfolded PrP(Sc) isoform in prion diseases. The prototype prion disease is scrapie in sheep, and whereas Prnp exhibits common mis...

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Bibliographic Details
Main Authors: Daude, Nathalie, Wohlgemuth, Serene, Rogaeva, Ekaterina, Farid, A. Hossein, Heaton, Mike, Westaway, David
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716538/
https://ncbi.nlm.nih.gov/pubmed/19657386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006538
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