Characterization of Conformation-Sensitive Antibodies to ADAMTS13, the von Willebrand Cleavage Protease

BACKGROUND: The zinc metalloprotease ADAMTS13 is a multidomain protein that cleaves von Willebrand Factor (VWF) and is implicated in Thrombotic Thrombocytopenic Purpura (TTP) pathogenesis. Understanding the mechanism of this protein is an important goal. Conformation sensitive antibodies have been u...

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Autori principali: Sauna, Zuben E., Okunji, Chinyere, Hunt, Ryan C., Gupta, Tanvi, Allen, Courtni E., Plum, Elizabeth, Blaisdell, Adam, Grigoryan, Vahan, S, Geetha, Fathke, Robert, Soejima, Kenji, Kimchi-Sarfaty, Chava
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716513/
https://ncbi.nlm.nih.gov/pubmed/19654870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006506
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