Characterization of Conformation-Sensitive Antibodies to ADAMTS13, the von Willebrand Cleavage Protease

BACKGROUND: The zinc metalloprotease ADAMTS13 is a multidomain protein that cleaves von Willebrand Factor (VWF) and is implicated in Thrombotic Thrombocytopenic Purpura (TTP) pathogenesis. Understanding the mechanism of this protein is an important goal. Conformation sensitive antibodies have been u...

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Detalhes bibliográficos
Main Authors: Sauna, Zuben E., Okunji, Chinyere, Hunt, Ryan C., Gupta, Tanvi, Allen, Courtni E., Plum, Elizabeth, Blaisdell, Adam, Grigoryan, Vahan, S, Geetha, Fathke, Robert, Soejima, Kenji, Kimchi-Sarfaty, Chava
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716513/
https://ncbi.nlm.nih.gov/pubmed/19654870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006506
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