QLT0267, a small molecule inhibitor targeting integrin-linked kinase (ILK), and docetaxel can combine to produce synergistic interactions linked to enhanced cytotoxicity, reductions in P-AKT levels, altered F-actin architecture and improved treatment outcomes in an orthotopic breast cancer model

INTRODUCTION: Substantial preclinical evidence has indicated that inhibition of integrin linked-kinase (ILK) correlates with cytotoxic/cytostatic cellular effects, delayed tumor growth in animal models of cancer, and inhibition of angiogenesis. Widely anticipated to represent a very promising therap...

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Detalhes bibliográficos
Main Authors: Kalra, Jessica, Warburton, Corinna, Fang, Karen, Edwards, Lincoln, Daynard, Tim, Waterhouse, Dawn, Dragowska, Wieslawa, Sutherland, Brent W, Dedhar, Shoukat, Gelmon, Karen, Bally, Marcel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716491/
https://ncbi.nlm.nih.gov/pubmed/19409087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr2252
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