From Synthesis to Biologics: Preclinical Data on a Chemistry Derived Anticancer Vaccine

A fully synthetic anticancer vaccine 2 has been prepared via bio-conjugation of unimolecular pentavalent construct 1 – containing five prostate and breast cancer associated carbohydrate antigens, Globo-H, GM2, STn, TF and Tn – to maleimide-modified carrier protein KLH. An improved conjugation protoc...

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Detalhes bibliográficos
Main Authors: Zhu, Jianglong, Wan, Qian, Lee, Dongjoo, Yang, Guangbin, Spassova, Maria K., Ouerfelli, Ouathek, Ragupathi, Govind, Damani, Payal, Livingston, Philip O., Danishefsky, Samuel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716484/
https://ncbi.nlm.nih.gov/pubmed/19518111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja901415s
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