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Distinct Structural Changes in the GABA(A) Receptor Elicited by Pentobarbital and GABA
The barbiturate pentobarbital binds to γ-aminobutyric acid type A (GABA(A)) receptors, and this interaction plays an important role in the anesthetic action of this drug. Depending on its concentration, pentobarbital can potentiate (∼10–100 μM), activate (∼100–800 μM), or block (∼1–10 mM) the channe...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2716461/ https://ncbi.nlm.nih.gov/pubmed/19167300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.09.037 |
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