Tolerance Induction to Cytoplasmic β-Galactosidase by Hepatic AAV Gene Transfer — Implications for Antigen Presentation and Immunotoxicity

BACKGROUND: Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins. Adequat...

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Detalhes bibliográficos
Main Authors: Martino, Ashley T., Nayak, Sushrusha, Hoffman, Brad E., Cooper, Mario, Liao, Gongxian, Markusic, David M., Byrne, Barry J., Terhorst, Cox, Herzog, Roland W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715858/
https://ncbi.nlm.nih.gov/pubmed/19652717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006376
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