Defective Histone Acetylation Is Responsible for the Diminished Expression of Cyclooxygenase 2 in Idiopathic Pulmonary Fibrosis

Diminished cyclooxygenase 2 (COX-2) expression in fibroblasts, with a resultant defect in the production of the antifibrotic mediator prostaglandin E(2), plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Here, we have characterized the molecular mechanism. We found that CO...

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Main Authors: Coward, William R., Watts, Keiria, Feghali-Bostwick, Carol A., Knox, Alan, Pang, Linhua
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715818/
https://ncbi.nlm.nih.gov/pubmed/19487460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01776-08
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