A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase-2 in idiopathic pulmonary fibrosis

Selective silencing of the cyclooxygenase-2 (COX-2) gene with the loss of the antifibrotic mediator prostaglandin E(2) contributes to the fibrotic process in idiopathic pulmonary fibrosis (IPF). This study explored the role of G9a- and enhancer of zeste homolog 2 (EZH2)-mediated methylation of histo...

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Autori principali: Coward, William R., Feghali-Bostwick, Carol A., Jenkins, Gisli, Knox, Alan J., Pang, Linhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Federation of American Societies for Experimental Biology 2014
Soggetti:
Research Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062820/
https://ncbi.nlm.nih.gov/pubmed/24652950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.13-241760
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