Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1β in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 Acetylation

Bradykinin and interleukin-1β (IL-1β) induce cyclooxygenase 2 (COX-2) in human airway smooth muscle cells. Here we extended our study to explore the gene transcriptional regulation. By transfection with various COX-2 promoter reporter constructs, we found that the bp −327-to-+59 promoter region was...

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Bibliographic Details
Main Authors: Nie, Mei, Pang, Linhua, Inoue, Hiroyasu, Knox, Alan J
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC309638/
https://ncbi.nlm.nih.gov/pubmed/14645533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9233-9244.2003
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