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Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1β in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 Acetylation
Bradykinin and interleukin-1β (IL-1β) induce cyclooxygenase 2 (COX-2) in human airway smooth muscle cells. Here we extended our study to explore the gene transcriptional regulation. By transfection with various COX-2 promoter reporter constructs, we found that the bp −327-to-+59 promoter region was...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC309638/ https://ncbi.nlm.nih.gov/pubmed/14645533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.24.9233-9244.2003 |
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