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Deficiency of Niemann-Pick Type C-1 Protein Impairs Release of Human Immunodeficiency Virus Type 1 and Results in Gag Accumulation in Late Endosomal/Lysosomal Compartments

Human immunodeficiency virus type 1 (HIV-1) relies on cholesterol-laden lipid raft membrane microdomains for entry into and egress out of susceptible cells. In the present study, we examine the need for intracellular cholesterol trafficking pathways with respect to HIV-1 biogenesis using Niemann-Pic...

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Main Authors: Tang, Yuyang, Leao, Ihid Carneiro, Coleman, Ebony M., Broughton, Robin Shepard, Hildreth, James E. K.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715784/
https://ncbi.nlm.nih.gov/pubmed/19474101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00259-09
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